Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction |
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Authors: | Fujii Hodaka |
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Institution: | Department of Pathology, New York University School of Medicine, 550 First Avenue, MSB-126, New York, NY 10016, USA. hodaka@med.nyu.edu |
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Abstract: | Binding of interleukin-2 (IL-2) to its specific receptor induces activation of two members of Jak family protein tyrosine kinases, Jak1 and Jak3. An IL-2 receptor (IL-2R)-reconstituted NIH 3T3 fibroblast cell line proliferates in response to IL-2 only when hematopoietic lineage-specific Jak3 is ectopically expressed. However, the mechanism of Jak3-dependent proliferation in the fibroblast cell line is not known. Here, I showed that Jak3 expression is dispensable for IL-2-induced activation of Jak1 and Stat proteins and expression of nuclear proto-oncogenes in the IL-2R-reconstituted fibroblast cell line. Jak3 expression markedly enhanced these IL-2-induced signaling events. In contrast, Jak3 expression was essential for induction of cyclin genes involved in the G1-S transition. These data suggest a critical role of Jak3 in IL-2 signaling in the fibroblast cell line and may provide further insight into the cell type-specific mechanism of cytokine signaling. |
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Keywords: | IL-2 Fibroblast Jak kinase Stat protein Proto-oncogene Cyclin |
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