5'-Amino-5'-deoxyaristeromycin and its antiviral properties |
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| Authors: | Rajappan Vasanthakumar P Schneller Stewart W |
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| Institution: | Department of Chemistry, Auburn University, Auburn, AL 36849, USA. |
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| Abstract: | An efficient, three-step synthesis of 5'-amino-5'-deoxyaristeromycin (5), from a protected form of aristeromycin (6), is described. Compound 5 was evaluated against a large number of viruses. It showed weak activity towards vaccinia, herpes simplex virus 2, and cytomegalovirus. No other activity was observed. Compound 5 displayed some cytotoxicity towards the host cell lines human foreskin fibroblast, Daudi, and human T-lymphocyte (CEM). |
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