On the detection of environmental effects on complex matrices combining off-line liquid chromatography and 1H-NMR |
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Authors: | Arjen Lommen Joop M Weseman Geo O Smith Hub PJM Noteborn |
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Institution: | (1) State Institute for Quality Control of Agricultural Products (RIKILT-DLO), P.O. Box 230, NL-6700 AE Wageningen, The Netherlands |
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Abstract: | An off-line combination of 400 MHz proton (1H)-NMR spectroscopy and liquid chromatography (LC) has been used for the multi-component comparison of low-molecular weight compounds (i.e., chemical fingerprinting) in model fluid broths and (processed) tomato. The focus of the research described is on (i) devising GLP-like methods for sample handling and NMR measurements that will ensure reproducibility, (ii) an automated handling of data, (iii) validity of the designed methodology and (iv) the interpretation of large amounts of data. |
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Keywords: | automation environment fingerprinting GLP LC NMR statistics |
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