Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli |
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Authors: | Yuzawa Satoshi Kim Woncheol Katz Leonard Keasling Jay D |
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Institution: | QB3 Institute, University of California, Berkeley, CA 94270, USA; Joint BioEnergy Institute, 5885 Hollis Street, Emeryville, CA 94608, USA. |
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Abstract: | Heterologous production of polyketide compounds, an important class of natural products with complex chemical structures, was first demonstrated with Streptomyces parvulus in 1984. Although Streptomyces strains are good first options for heterologous polyketide biosynthesis, their slow growth kinetics prompt other hosts to also be considered. Escherichia coli provides key elements of an ideal host in terms of the growth rate, culture conditions, and available recombinant DNA tools. Here we review the current status and potential for metabolic engineering of polyketides in E. coli. |
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