A yeast artificial chromosome contig spanning the mouse immunoglobulin kappa light chain locus |
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| Authors: | Ingo W. Schupp Thomas Schlake Thomas Kirschbaum Hans G. Zachau T. Boehm |
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| Affiliation: | Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany, DE
Adolf-Butenandt-Institut für Physiologische Chemie der Universit?t München, Schillerstra?e 44, D-80366 München, Germany, DE
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| Abstract: | A single contig spanning the entire mouse immunoglobulin kappa light chain (Igk) locus on chromosome 6 has been established using yeast and bacterial artificial chromosome clones. Detailed mapping of the Igk locus indicates that a member of the Igk-V2 gene family, located about 3.5 megabases upstream of the Igk-J-C complex, is the most distal functional Igk-V gene. Sequence analyses of Igk-V genes and anonymous DNA segments provide indications for internal duplications at the 5′ end of the Igk-V locus and identify the likely origin of Igk-V orphon gene clusters located elsewhere in the mouse genome. Received: 17 July 1996 / Revised: 2 September 1996 |
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