| Abstract: | Sukumar, Minakshi, Mahesh Bommaraju, John E. Fisher,Frederick C. Morin III, Michele C. Papo, Bradley P. Fuhrman, Lynn J. Hernan, and Corinne Lowe Leach. High-frequency partial liquidventilation in respiratory distress syndrome: hemodynamics and gasexchange. J. Appl. Physiol. 84(1):327-334, 1998. Partial liquid ventilation using conventionalventilatory schemes improves lung function in animal models ofrespiratory failure. We examined the feasibility of high-frequencypartial liquid ventilation in the preterm lamb with respiratorydistress syndrome and evaluated its effect on pulmonary and systemichemodynamics. Seventeen lambs were studied in three groups:high-frequency gas ventilation (Gas group), high-frequency partialliquid ventilation (Liquid group), and high-frequency partial liquidventilation with hypoxia-hypercarbia (Liquid-Hypoxiagroup). High-frequency partial liquid ventilation increased oxygenation compared with high-frequency gas ventilation over5 h (arterial oxygen tension 253 ± 21.3 vs. 17 ± 1.8 Torr; P < 0.001).Pulmonary vascular resistance decreased 78%(P < 0.001), pulmonary blood flowincreased fivefold (P < 0.001), andaortic pressure was maintained (P < 0.01) in the Liquid group, in contrast to progressive hypoxemia,hypercarbia, and shock in the Gas group. Central venouspressure did not change. The Liquid-Hypoxia group was similar tothe Gas group. We conclude that high-frequency partial liquidventilation improves gas exchange and stabilizes pulmonary and systemichemodynamics compared with high-frequency gas ventilation. Thestabilization appears to be due in large part to improvement in gasexchange. |
