Angiotensin II inhibits L-type voltage-dependent Ca(2+)-current in smooth muscle cells from the rat aorta

Macroscopic voltage-activated L-type Ca2+ currents were blocked by angiotensin II (A11), the effect being inhibited by losartan. A rise in internal Ca2+ evoked by the A11, occurred, losartan being ineffective in these cases. The AT1 receptors seem to be involved in the effect of the A11 on the L-type Ca2+ current in aortic smooth muscle cells.