The relationship between ultrasonographically measured testicular volumes and cord blood inhibin B concentrations in healthy term male neonates |
| |
| Affiliation: | 1. Celal Bayar University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Manisa, Turkey;2. Celal Bayar University, Faculty of Medicine, Department of Radiology, Manisa, Turkey;3. Ege University, Faculty of Medicine, Department of Pediatrics, İzmi̇r, Turkey;4. Celal Bayar University, Faculty of Medicine, Department of Clinical Biochemistry, Manisa, Turkey;5. Celal Bayar University, Faculty of Medicine, Department of Public Health, Mani̇sa, Turkey;6. İstinye University, School of Medicine, Department of Pediatrics, Division of Neonatalogy, İstanbul, Turkey;1. Center for Pharmacy and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, GA, USA;2. Charlie Norwood VA Medical Center, Augusta, GA, USA;3. Department of Biochemistry and Molecular Biology, Augusta University, Augusta, GA, USA;4. Vascular Biology Center, Department of Pharmacology and Toxicology, Augusta University, Augusta, GA, USA;5. Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA;1. Department of Mesenchymal Stem Cells, Academic Center for Education, Culture, and Research (ACECR), Qom Branch, Qom, Iran;2. Department of Reproductive Biology, Academic Center for Education, Culture, and Research (ACECR), Qom Branch, Qom, Iran;3. Midwifery ward, Infertility treatment center, Academic Center for Education, Culture, and Research (ACECR), Qom Branch, Qom, Iran;1. Department of Histology and Embryology, Faculty of Medicine and Dentistry, Pomeranian Medical University (PUM), Powstańców Wlkp 72, 70-111 Szczecin, Poland;2. Department of Nephrology, Transplantology and Internal Medicine, Faculty of Medicine and Dentistry, PUM, Powstańców Wlkp 72, 70-111 Szczecin, Poland |
| |
| Abstract: | Serum inhibin B (INHB) concentrations are associated with testicular volumes (TV) in all periods of childhood. The aim of the study was to investigate the relationship between TV measured by ultrasonography (US) and cord blood inhibin B and total testosterone (TT) concentrations, stratified by mode of delivery. In total 90 male infants were included. Testes of healthy, term newborns were evaluated by US on the third day after delivery. TV were calculated using two formulae: The ellipsoid formula [length (mm) × width (mm2) × π/6] and Lambert formula [length (mm) x width (mm) x height (mm) x 0.71]. Cord blood was taken for the determination of total testosterone (TT) and INHB. TT and INHB concentrations were evaluated according to TV percentiles (<10th, 10th-90th, >90th). There was a strong positive correlation between mean TV calculated with both formulae by percentile group (r = 0.777, r = 0.804, r = 0.846; p < 0.001). Cord blood INHB, but not TT were significantly lower in newborns with TV < 10th percentile compared to those with TV between 10 and 90th percentile and > 90th percentile (p < 0.05). There was a positive correlation between left and right TV calculated by either formula, and cord blood INHB (r = 0.212, 0.313, 0.320, 0.246, p < 0.05), not TT. There was no significant difference between hormones and TV when grouped by mode of delivery (p > 0.05). The Lambert and ellipsoid formulas are equally reliable in calculating neonatal testicular by ultrasound. INHB concentration is high in cord blood and positively correlated with neonatal TV. Cord blood INHB concentration may be an indicator for early detection of testicular structure and function disorders in neonates. |
| |
| Keywords: | Neonate Testicular volume Cord blood Inhibin B Ultrasonography |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
