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Transcriptomic profile of GLCs of PCOS women highlights metabolic dysregulation as a plausible contributor to PCOS pathophysiology
Affiliation:1. Department of Molecular Endocrinology, National Institute for Research in Reproductive and Child Health, Indian Council of Medical Research, J.M. Street, Parel, Mumbai 400012, India;2. P. D. Hinduja National Hospital and Medical Research Centre, Mahim, Mumbai 400016, India;1. Department of General Surgery, Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, PR China;2. Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, PR China;3. Department of Medical Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, PR China;1. Division of Clinical Embryology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576 104, India;2. Dipartimento di Biologia, Università di Napoli "Federico II", Complesso Universitario di Monte S Angelo, Napoli, Italy;3. Division of Reproductive Genetics, Department of Reproductive Science, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576 104, India;4. Department of Data Science, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal 576104, India;5. Division of Reproductive Biology, Department of Reproductive Science, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576 104, India;1. Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland;2. Department of Animal Nutrition and Biotechnology, and Fisheries, Faculty of Animal Science, University of Agriculture in Krakow, al. Mickiewicza 21, 31-120 Krakow, Poland;1. Western China Science and Technology Innovation Port in Precision Medicine Institute, The Second Affiliated Hospital of Xi''an Jiaotong University, Xi''an, PR China;2. Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an 710061, PR China;3. Department of Urology, The First Affiliated Hospital of Xi''an Jiaotong University, Xi''an, Shaanxi 710061, PR China;4. National-Local Joint Engineering Research Center of Biodiagnosis & Biotherapy, The Second Affiliated Hospital, Xi''an Jiaotong University, Xi''an, PR China;1. Department of Pathophysiology/Key Laboratory of High Altitude Environment Medicine, Ministry of Education/Key Laboratory of High Altitude Medicine, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, PR China;2. Chongqing ILinda Biomedical Research Corporation Limited, PR China;3. Department of High Altitude Operational Medicine, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, PR China
Abstract:
Keywords:Polycystic ovary syndrome  RNA-Seq  Angiogenesis  Metabolism  IVF
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