Effect of respiratory syncytial virus on the growth of hepatocellular carcinoma cell-lines |
| |
| Authors: | Song Hee Choi Byoung Kwon Park Keun-Wook Lee Jun Chang Younghee Lee Hyung-Joo Kwon |
| |
| Institution: | 1.Departments of Microbiology, College of Medicine, Hallym University, Chuncheon 24252;2.Departments of Biomedical Science, College of Natural Science, Hallym University, Chuncheon 24252;3.Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760;4.Department of Biochemistry, College of Natural Sciences, Chungbuk National University, Cheongju 28644;5.Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon 24252, Korea |
| |
| Abstract: | In several reports, the respiratory syncytial virus (RSV) was identified as an oncolytic virus in cancer cells (e.g., lung and prostate cancer). However, the effects of RSV in hepatocellular carcinoma (HCC) cells have not yet been investigated. Here, we observed the inhibitory effects of RSV infection in HCC cell-lines. Cell growth was significantly decreased by RSV infection in BNL-HCC, Hep3B, Huh-7 and SNU-739 cells. After RSV infection, plaque formation and syncytial formation were observed in affected Hep3B and Huh-7 cells. RSV protein-expression was also detected in Hep3B and Huh-7 cells; however, only Huh-7 cells showed apoptosis after RSV infection. Furthermore, inhibition of cell migration by RSV infection was observed in BNL-HCC, Hep3B, Huh-7 and SNU-739 cells. Therefore, further investigation is required to clarify the molecular mechanism of RSV-mediated inhibition of HCC cell growth, and to develop potential RSV oncolytic viro-therapeutics. BMB Reports 2015; 48(10): 565-570] |
| |
| Keywords: | Apoptosis Cell growth Hepatocellular carcinoma Oncolytic effect RSV |
|
|
