Metabolic control of the cell cycle |
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Authors: | Joanna Kalucka Rindert Missiaen Maria Georgiadou Sandra Schoors Christian Lange Katrien De Bock Mieke Dewerchin Peter Carmeliet |
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Affiliation: | 1.Laboratory of Angiogenesis and Neurovascular link; Department of Oncology; KU Leuven; Leuven, Belgium;2.Laboratory of Angiogenesis and Neurovascular link; Vesalius Research Center; VIB, Leuven, Belgium;3.Present address: Turku Centre for Biotechnology; Turku, Finland;4.Present address: Exercise Physiology Research Group; Department of Kinesiology; KU Leuven; Leuven, Belgium |
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Abstract: | Cell division is a metabolically demanding process, requiring the production of large amounts of energy and biomass. Not surprisingly therefore, a cell''s decision to initiate division is co-determined by its metabolic status and the availability of nutrients. Emerging evidence reveals that metabolism is not only undergoing substantial changes during the cell cycle, but it is becoming equally clear that metabolism regulates cell cycle progression. Here, we overview the emerging role of those metabolic pathways that have been best characterized to change during or influence cell cycle progression. We then studied how Notch signaling, a key angiogenic pathway that inhibits endothelial cell (EC) proliferation, controls EC metabolism (glycolysis) during the cell cycle. |
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Keywords: | angiogenesis cell cycle endothelial cell metabolism quiescence |
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