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Design principles for robust biochemical reaction networks: what works, what cannot work, and what might almost work |
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| Authors: | Shinar Guy Feinberg Martin |
| Institution: | a Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel b The William G. Lowrie Department of Chemical and Biomolecular Engineering, Ohio State University, 140 W. 19th Avenue, Columbus, OH 43210, USA c Department of Mathematics, Ohio State University, 140 W. 19th Avenue, Columbus, OH 43210, USA |
| Abstract: | We bring together recent results that connect the structure of a mass-action reaction network to its capacity for concentration robustness — that is, its capacity to keep the concentration of a critical bio-active species within narrow limits, even against large fluctuations in the overall supply of the network’s constituents. |
| Keywords: | Network Reaction network Robust Systems biology Design principles |
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