Schistosoma japonicum: Immunopathology of nephritis in Macaca fascicularis |
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Authors: | Tomio Tada Yoichiro Kondo Ko Okumura Motohito Sano Muneo Yokogawa |
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Institution: | Department of Pathology and Department of Parasitology, School of Medicine, Chiba University, Chiba, Japan |
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Abstract: | Macaca monkeys experimentally infected with Schistosoma japonicum developed a chronic progressive kidney lesion characterized by an increase of mesangial matrix, local glomerular hypercellularity, and local thickening of glomerular basement membrane. Immunofluorescence studies revealed the localization of IgG, IgM, IgA, and IgE immunoglobulins mostly in the mesangial area of the glomeruli accompanied by the deposition of Schistosoma antigens. By electron microscopy, in addition to the local thickening of the glomerular basement membrane, dense homogeneous deposits and those with moth-eaten appearance were detected in the mesangial matrix. These findings suggest that worms in the bloodstream continuously release antigenic materials that stimulate host's antibody response belonging to various immunoglobulin classes including IgE. The produced antibodies and antigens would form immune complexes that deposited in the glomeruli. The increased vascular permeability caused by antigen-IgE antibody interaction may play an important role in the deposition of immune complexes and in the rapid development of kidney injury. |
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Keywords: | Prausnitz-Küstner (P-K) reaction Immunofluorescence Immunoglobulins IgG IgA IgM IgE Immune complexes Immune deposits Glomerulosclerosis hepatic Kidneys Pathology Monkeys Rabbits Goats Immunoelectrophoresis Chromatography column Electrophoresis |
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