Quantitative discrimination of NPC cell lines using optical coherence tomography |
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| Authors: | Jianghua Li Changshui Chen Bingling Chen Zhiyuan Shen Yonghong He Yunfei Xia Songhao Liu |
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| Affiliation: | 1. School for Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, China;2. Laboratory of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China;3. Department of Radiation Oncology, Cancer Center, Sun Yat‐sen University of Medical Sciences, Guangzhou 510060, China |
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| Abstract: | We tried to explore the intrinsic differences in the optical properties of the four representative NPC cell lines on the models of radiobiology and metastasis by OCT. The scattering coefficients and anisotropies were extracted by fitting the average a‐scan attenuation curves based on the multiple scatter effect. The values of scattering coefficients and anisotropy factors were 5.21 ± 0.11, 5.30 ± 0.09, 5.92 ± 0.21, 6.97 ± 0.22, and 0.892 ± 0.009, 0.886 ± 0.006, 0.884 ± 0.009, 0.86 ± 0.01 for CNE1, CNE2, 5‐8F and 6‐10B pellets (p < 0.05, P = 0.07 for CNE1 and CNE2), respectively. The results showed that the radiobiology and metastasis cell's model could be distinguished obviously; which implied that the corresponding types of NPC tissue might be potentially differentiated by OCT. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) |
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| Keywords: | nasopharyngeal carcinoma (npc) cell lines optical coherence tomography (OCT) attenuation coefficient anisotropy |
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