Proton transfers in the bacteriorhodopsin photocycle |
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Authors: | Lanyi Janos K |
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Affiliation: | Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA. jlanyi@orion.oac.uci.edu |
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Abstract: | The steps in the mechanism of proton transport in bacteriorhodopsin include examples for most kinds of proton transfer reactions that might occur in a transmembrane pump: proton transfer via a bridging water molecule, coupled protonation/deprotonation of two buried groups separated by a considerable distance, long-range proton migration over a hydrogen-bonded aqueous chain, and capture as well as release of protons at the membrane-water interface. The conceptual and technical advantages of this system have allowed close examination of many of these model reactions, some at an atomic level. |
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