Separation of albendazole sulfoxide enantiomers by chiral supercritical-fluid chromatography |
| |
| Authors: | del Nozal M J Toribio L Bernal J L Nieto E M Jiménez J J |
| |
| Affiliation: | Department of Analytical Chemistry, Faculty of Sciences, University of Valladolid, Prado de la Magdalena s/n, E-47005 Valladolid, Spain. mjdnozal@qu.uva.es |
| |
| Abstract: | The enantioseparation of albendazole sulfoxide (ABZSO) by chiral supercritical-fluid chromatography (SFC) on two columns, based on the polysaccharide derivatives Chiralpak AD and Chiralcel OD, was studied. The effect of different modifiers, methanol, ethanol, 2-propanol, and acetonitrile, was examined. The results showed that ABZSO can be separated on both columns, using an alcohol-type modifier. Using the Chiralpak AD column, the best results were obtained with 2-propanol and, in the case of the Chiralcel OD, with methanol. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
