Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes |
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| Authors: | Adam Baldwin Michael Loughlin Juncal Caubilla-Barron Eva Kucerova Georgina Manning Christopher Dowson and Stephen Forsythe |
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| Institution: | (1) Biological Sciences Department, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK;(2) School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK |
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| Abstract: | Background The Cronobacter genus (Enterobacter sakazakii) has come to prominence due to its association with infant infections, and the ingestion of contaminated reconstituted infant
formula. C. sakazakii and C. malonaticus are closely related, and are defined according their biotype. Due to the ubiquitous nature of the organism, and the high
severity of infection for the immunocompromised, a multilocus sequence typing (MLST) scheme has been developed for the fast
and reliable identification and discrimination of C. sakazakii and C. malonaticus strains. It was applied to 60 strains of C. sakazakii and 16 strains of C. malonaticus, including the index strains used to define the biotypes. The strains were from clinical and non-clinical sources between
1951 and 2008 in USA, Canada, Europe, New Zealand and the Far East. |
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