Phencyclidine-induced ipsilateral rotation in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra |
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Authors: | R G Fessler R D Sturgeon H Y Meltzer |
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Affiliation: | 1. Laboratory of Biological Psychiatry, Illinois State Psychiatric Institute, USA;2. Dept. of Psychiatry, University of Chicago Pritzker School of Medicine, USA |
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Abstract: | The effect of phencyclidine (PCP) on rotational behavior in rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the substantia nigra was examined and compared to the effects of d-amphetamine and apomorphine. PCP, like d-amphetamine, induced ipsilateral rotation indicating a presynaptic effect on dopamine (DA) neurons whereas apomorphine, a direct acting agonist, caused contralateral rotation. Pretreatment with alpha-methyparatyrosine inhibited PCP-induced rotation approximately to the same extent as it inhibited d-amphetamine-induced rotation, but did not significantly reduce apomorphine-induced contralateral turning, further indicating that PCP has a presynaptic effect on DA neurons. Anti-cholinergic effects on PCP may also contribute to the ipsilateral rotation noted. |
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