A dynamic model of renal blood flow autoregulation |
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Authors: | N -H Holstein-Rathlou D J Marsh |
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Institution: | (1) Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark;(2) Department of Physiology and Biophysics, Brown University, 02912 Providence, RI, U.S.A. |
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Abstract: | To test whether a mathematical model combining dynamic models of the tubuloglomerular feedback (TGF) mechanism and the myogenic
mechanism was sufficient to explain dynamic autoregulation of renal blood flow, we compared model simulations with experimental
data. To assess the dynamic characteristics of renal autoregulation, a broad band perturbation of the arterial pressure was
employed in both the simulations and the experiments. Renal blood flow and tubular pressure were used as response variables
in the comparison. To better approximate the situationin vivo where as large number of individual nephrons act in parallel, each simulation was performed with 125 parallel versions of
the model. The key parameters of the 125 versions of the model were chosen randomly within the physiological range. None of
the constituent models, i.e., the TGF and the myogenic, could alone reproduce the experimental observations. However, in combination
they reproduced most of the features of the various transfer functions calculated from the experimental data. The major discrepancy
was the presence of a bimodal distribution of the admittance phase in the simulations. This is not consistent with most of
the experimental data, which shows a unimodal curve for the admittance phase. The ability of the model to reproduce the experimental
data supports the hypothesis that dynamic autoregulation of renal blood flow is due to the combined action of TGF and the
myogenic response. |
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