The effect of a benzodiazepine antagonist, RO15-1788, in diazepam dependent rats |
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Authors: | L F McNicholas W R Martin |
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Institution: | Department of Pharmacology University of Kentucky College of Medicine Research Facility #2, MR-109 Lexington, Kentucky 40536, USA |
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Abstract: | A benzodiazepine antagonist, RO15-1788, was administered intragastrically to diazepam-dependent gastric fistula rats and a precipitated abstinence syndrome was observed. The intensity of the RO15-1788 precipitated abstinence syndrome, calculated by the Precipitated Abstinence Scale, increased in intensity in a log-dose manner over a dose range of 1.0 to 15.0 mg/kg of RO15-1788 and plateaued at the 15.0 mg/kg dose. The RO15-1788 precipitated diazepam abstinence syndrome differed both qualitatively and quantitatively from the diazepam withdrawal syndrome. |
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