The chromosome-breaking activity of the restriction endonuclease Alu I in CHO cells is independent of the S-phase of the cell cycle |
| |
| Authors: | G Obe E U Winkel |
| |
| Affiliation: | Institut für Genetik, Freie Universität Berlin, Arnimallee 5-7, D-1000 Berlin 33, F.R.G. |
| |
| Abstract: | The restriction endonuclease Alu I induces chromosomal aberrations in living Chinese hamster ovary (CHO) cells. Multiple fixation times reveal that the chromosome-breaking activity of Alu I is similar to that of ionizing radiation in that it is independent of the S-phase of the cell cycle. These results indicate that DNA double-strand breaks are the ultimate lesions for the production of chromosomal aberrations in all stages of the cell cycle. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
