Ionic regulation of cyclic AMP levels in Paramecium tetraurelia in vivo |
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Authors: | E. Machicao O.H. Wieland |
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Affiliation: | Institut für Klinische Chemie und Forschergruppe Diabetes, Städtisches Krankenhaus München-Schwabing, Kölner Platz 1, 8000 München 40, FRG |
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Abstract: | cAMP levels in Paramecium increased dose dependently after a step increase of [Ca] or [Sr] in the incubation, provided K was present. Two mM Ca or Sr tripled cAMP concentrations within 3 s and induced an increase in forward swimming speed. The increase in cAMP formation was strictly dependent on the Donnan ratio [K]: square root [Ca]. Na, Li, or tetraethylammonium could not replace K. The data provide evidence for regulation of cAMP in Paramecium by the membrane surface charge as determined specifically by the regulation of cAMP in Paramecium by the membrane surface charge as determined specifically by the K: Ca ratio. |
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Keywords: | Insulin receptor Tyrosine kinase Signal transduction Phosphoinositide system Second messenger |
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