Familial fragility on chromosome 16 (Fra 16q22) enhanced by both interferon and distamycin A |
| |
Authors: | Fiorella Shabtai Dvora Klar S Bichacho J Hart I Halbrecht |
| |
Institution: | 1. B. Gattegno Research Institute of Human Reproduction and Fetal Development, Hasharon Hospital, Petah Tikva, Israel 2. Tel Aviv University Medical School, Israel
|
| |
Abstract: | A family with a "fragile site" at 16q22, inducible by both interferon and Distamycin A, is reported. Immunological problems were found in the family. In a sibship of ten, eight children had died in infancy. Our study led to the conclusions that interferon and Distamycin A induce fragility at the same site, which has the same characteristics as the spontaneous fragile site; that a viral hypothesis for this fragility may be supported; and that immunoincompetence of one kind or another must be considered in families presenting a fragile site at 16q22. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|