Cytochrome P-450-dependent catabolism of triethanolamine in Rhodotorula mucilaginosa |
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Authors: | A. N. Fattakhova E. N. Ofitserov A. V. Garusov |
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Affiliation: | (1) The Kazan State University, 420008 Kazan, USSR |
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Abstract: | The yeast Rhodotorula mucilaginosa was able to grow in media containing triethanolamine or diethanolamine as the sole nitrogen source. During growth in the presence of triethanolamine, extracts of yeast cells contained increased levels of cytochrome P-450 dependent monooxygenase which catalyzed the oxidative N-dealkylation of aminoalcohols. Formation of diethanolamine, ethanolamine and glyoxylate from triethanolamine was demonstrated, and the identity of the products was verified by thin layer chromatography. These observations suggested the following scheme of triethanolamine catabolism: triethanolamine diethanolamine + glycolaldehyde, diethanolamine ethanolamine + glycolaldehyde, ethanolamine NH3 + glycolaldehyde glycolate glyoxylate glycerate pathway. |
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Keywords: | cytochrome P-450 triethanolamine |
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