Computational studies on pterins and speculations on the mechanism of action of dihydrofolate reductase |
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| Authors: | T Uchimaru S Tsuzuki K Tanabe S J Benkovic K Furukawa K Taira |
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| Institution: | National Chemical Laboratory for Industry, Agency of Industrial Science and Technology, Tsukuba Science City, Japan. |
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| Abstract: | The significance of the enol form of the pterin ring in enzymatic reduction of dihydrofolate by DHFR is discussed on the basis of the results of ab initio calculations carried out on the keto/enol tautomers of 6-methyl-7, 8-dihydropterin as the model compound for the natural substrate, dihydrofolate. |
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