Synthetic oligosaccharides having various functional domains: potent and potentially safe heparin mimetics. |
| |
| Authors: | M Petitou P A Driguez P Duchaussoy J P Hérault J C Lormeau J M Herbert |
| |
| Affiliation: | Sanofi Recherche, Haemobiology Research Department, Toulouse, France. |
| |
| Abstract: | A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide sequence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a protein released by activated platelets. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
