Feeding induced by opiates injected into the paraventricular hypothalamus |
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Authors: | S McLean B G Hoebel |
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Affiliation: | Department of Psychology, Princeton University, Princeton, NJ 08544 USA |
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Abstract: | Injection of morphine or d-ala-2-met-5-enkephalinamide (DALA) into the paraventricular nucleus of the hypothalamus (PVN) produced a dose dependent increase in feeding in rats. DALA increased feeding within 45 minutes; morphine within 90 minutes. Naloxone injected into the PVN diminished the effect. DALA increased water intake only when food was available, suggesting the primary effect was on feeding. In summary, an enkephalin analogue induced feeding, and an opiate receptor blocker attenuated it; therefore the PVN may contain opiate receptors that facilitate feeding. |
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Keywords: | Opiates Enkephalin Feeding Paraventricular nucleus Hypothalamus |
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