Chemical neuroprotection in the cochlea: the modulation of dopamine release from lateral olivocochlear efferents |
| |
Authors: | Lendvai Balázs Halmos György B Polony Gábor Kapocsi Judit Horváth Tamás Aller Máté Sylvester Vizi E Zelles Tibor |
| |
Institution: | a Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary b Gedeon Richter Plc., Budapest, Hungary c Department of Otolaryngology, Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands d Department of Otorhinolaryngology Head and Neck Surgery, Semmelweis University, Budapest, Hungary e 1st Department of Internal Medicine, Semmelweis University, Budapest, Hungary |
| |
Abstract: | The prevalence of sensorineural hearing loss is increasing worldwide, mainly due to ageing, increased noise exposure and cardiovascular risk factors. Several papers dealt with the mechanisms underlying the primary causes of impaired hearing and eventual deafness, including the damage and loss of auditory hair cells; however, very little is known about the protective mechanisms that exist for hearing. Several recent investigations have implicated dopamine (DA) in a neuroprotective circuit for the cochlea. The lateral olivocochlear (LOC) efferents provide axonal innervation of the inner hair cell afferent synapses and release DA and other substances in response to different stimuli. Under ischemic conditions or during noise exposure, DA has been proven to play a neuroprotective role against glutamate excitotoxicity. This review summarises what is currently known about the modulation of DA release in the cochlea, using primarily in vitro experimental data. Based on recent knowledge, there could be two functional subgroups within the LOC fibres, i.e., the DA- and GABA-containing projections. In this review, we attempt to show the neurochemical interactions between these two subsystems. Other aspects of cochlear neurotransmission are also discussed to provide a complete picture of cochlear dopaminergic function in physiological and pathophysiological cases with particular reference to excitotoxicity. |
| |
Keywords: | AICA anterior inferior cerebellar artery CM cochlear microphonic CAP compound action potential DPOAE distortion product otoacoustic emission DA dopamine IHC inner hair cells LOC lateral olivocochlear LSO lateral superior olive NOS nitric oxide synthase NIHL noise-induced hearing loss OHCs outer hair cells OGD oxygen-glucose deprivation SNHL sensorineural hearing loss 5-HT serotonin SP summating potentials TTX tetrodotoxin TH tyrosine hydroxylase VGCCs voltage-gated Ca2+-channels |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|