Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells |
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Authors: | Kiem Phan Van Thuy Nguyen Thi Kim Anh Hoang Le Tuan Nhiem Nguyen Xuan Minh Chau Van Yen Pham Hai Ban Ninh Khac Hang Dan Thuy Tai Bui Huu Tuyen Nguyen Van Mathema Vivek Bhakta Koh Young-Sang Kim Young Ho |
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Institution: | aCollege of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea;bInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam;cViettri University of Industry, Viettri, Viet Nam;dInstitute of Chemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam;eSchool of Medicine and Brain Korea 21 Program, Jeju National University, Jeju 690-756, South Korea |
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Abstract: | The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, three new labdane-type diterpenes 1–3, named coronarins G–I as well as seven known 4–10, coronarin D, coronarin D methyl ether, hedyforrestin C, (E)-nerolidol, β-sitosterol, daucosterol, and stigmasterol were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance spectroscopy. They were evaluated for inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1, 2, and 6 were significant inhibitors of LPS-stimulated TNF-α, IL-6, and IL-12 p40 productions with IC50 ranging from 0.19 ± 0.11 to 10.38 ± 2.34 μM. The remains of compounds showed inactivity or due to cytotoxicity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-type diterpenes from H. coronarium. |
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Keywords: | Hedychium coronarium Zingiberaceae Labdane Coronarins G&ndash I TNF-α IL-6 IL-12 |
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