Minicells: versatile vectors for targeted drug or si/shRNA cancer therapy |
| |
Authors: | MacDiarmid Jennifer A Brahmbhatt Himanshu |
| |
Institution: | EnGeneIC Ltd, Cancer Therapeutics, Building 2, 25 Sirius Road, Lane Cove West, Sydney, NSW 2066, Australia |
| |
Abstract: | Effective cancer therapy continues to be a daunting challenge due mainly to considerable tumor cell heterogeneity, drug-resistance, and dose-limiting toxicity of therapeutics. Here we review a versatile nano-cellular (minicell) delivery vehicle that can be packaged with therapeutically effective concentrations of chemotherapeutic drugs, siRNAs or shRNAs and can be targeted to tumors via minicell-surface attached bispecific antibodies. A range of minicell-based therapeutics have shown highly effective tumor stabilization/regression in the murine xenograft model and in case studies in canines with late-stage endogenous tumors. Repeat intravenous dosing shows absence of toxicity or immunogenicity in both species. The minicell-based therapeutic has potential applications in personalized cancer medicine. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|