Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum |
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| Authors: | Cheng Yong-Xian Zhou Li-Li Yan Yong-Ming Chen Ke-Xin Hou Fan-Fan |
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| Affiliation: | aState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China;bDivision of Nephrology, Nanfang Hospital, Southern Medical University, Key Laboratory for Organ Failure Research, Education Ministry, Guangzhou 510515, Guangdong, PR China |
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| Abstract: | Three new cyclic peptides, namely duanbanhuains A–C (1–3), were isolated from the roots of Brachystemma calycinum which is a traditional medicine used to treat rheumatic diseases. Their structures were identified by means of a suite of MS and NMR experiments. These compounds were purposely evaluated for their inhibitory effects on the release of MCP-1, IL-6, collagen IV and reactive oxygen species (ROS) against high-glucose-stimulated mesangial cells. The results showed that compounds 1 and 2 exhibited potent inhibition on the production of IL-6, collagen IV and ROS at the concentration of 10 μM. |
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| Keywords: | Brachystemma calycinum Caryophyllaceae Cyclic peptides Cytokines Collagen IV ROS |
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