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Tetrazole based amides as growth hormone secretagogues |
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| Authors: | Li James J Wang Haixia Li Jun Qu Fucheng Swartz Stephen G Hernández Andrés S Biller Scott A Robl Jeffrey A Tino Joseph A Slusarchyk Dorothy Seethala Ramakrishna Sleph Paul Yan Mujing Grover Gary Flynn Neil Murphy Brian J Gordon David |
| Institution: | Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08543-5400, USA. James.Li@bms.com |
| Abstract: | A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model. |
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