Hypoxia-Induced Lipid Peroxidation in Rat Brain and Protective Effect of Carnitine and Phosphocreatine |
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| Authors: | Rauchová Hana Koudelová Jitka Drahota Zdenek Mourek Jind?ich |
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| Institution: | (1) Institute of Physiology, Academy of Sciences of the Czech Republic, Czech Republic;(2) Centre for Experimental Cardiovascular Research, 142 20, Prague 4, Czech Republic;(3) Institute of Physiology, First Faculty of Medicine, Charles University, 128 00, Prague 2, Czech Republic |
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| Abstract: | The exposure to hypobaric hypoxia increased lipid peroxidation (as indicated by thiobarbituric acid-reactive substances TBARS] in rat brain. Plasma lactate/pyruvate ratio was used as a marker of hypoxia. We compared the protective effect of  -tocopherol with the effect of l-carnitine or phosphocreatine. Rats pretreated with -tocopherol, l-carnitine, or phosphocreatine had lower TBARS levels after the exposure to hypobaric hypoxia. However, lactate/pyruvate ratio was improved only in rats pretreated with l-carnitine or phosphocreatine. We conclude from our data that, contrary to -tocopherol, protective effects of l-carnitine and phosphocreatine administrations are due to their regulation of metabolic reactions during hypobaric hypoxia rather than to their scavenger activity. |
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| Keywords: | Brain (rat) hypobaric hypoxia lipid peroxidation carnitine phosphocreatine lactate/pyruvate ratio |
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