Phylogenetic assessment of alignments reveals neglected tree signal in gaps |
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| Authors: | Christophe Dessimoz Manuel Gil |
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| Affiliation: | 1.Department of Computer Science,ETH Zurich,Zürich,Switzerland;2.Swiss Institute of Bioinformatics,Zurich,Switzerland |
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| Abstract: | Background The alignment of biological sequences is of chief importance to most evolutionary and comparative genomics studies, yet the two main approaches used to assess alignment accuracy have flaws: reference alignments are derived from the biased sample of proteins with known structure, and simulated data lack realism. |
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