The effect of berberine administration to rats on the functional state of liver after common bile duct ligation |
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| Authors: | I V Zverinsky N G Melnichenko V A Poplavsky I P Sutsko P G Telegin A G Shlyahtun |
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| Institution: | (1) Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey;(2) Department of General Surgery, Gazi University Faculty of Medicine, Ankara, Turkey;(3) Department of Biochemistry, Kecioren Training and Research Hospital, Ankara, Turkey;(4) Department of Pathology, Diskapi Training and Research Hospital, Ankara, Turkey;(5) Department of Pathology, Gazi University Faculty of Medicine, Ankara, Turkey |
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| Abstract: | On day 8 after ligation of the common bile duct in rats a significant increase in the serum content of total lipids, cholesterol, bilirubin and ALT, alkaline phosphatase, and gamma-glutamyltransferase was observed. In the hepatic microsomal fraction there was a marked decrease in the content and activity of microsomal monooxygenases. Introperitoneal injections of berberine (10 mg/kg) for 6 days caused a partial normalization of hepatocyte plasma permeability and activity of microsomal flavin-containing monooxygenases. It is suggested that berberine is a substrate and inducer of flavin-containing monooxygenases. The membrane-stabilizing effect of berberine is probably realized at the level of inhibition of the prooxidant status of liver cells. |
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