A more accurate profile of Achyrocline satureioides hypocholesterolemic activity |
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Authors: | Espiña Débora Corrêa Carvalho Fabiano Barbosa Zanini Daniela Schlemmer Josiane Bizzi Coracini Juliane Dors Rubin Maribel Antonello Morsch Vera Maria Schetinger Maria Rosa Chitolina Leal Daniela Bitencourt Rosa Baiotto Cléia Rosani Jaques Jeandre Augusto dos Santos |
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Affiliation: | Curso de Ciências Biológicas, Centro de Ciências da Saúde, Laboratório de Biologia Molecular, Universidade de Cruz Alta, Cruz Alta, RS, Brazil. |
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Abstract: | The aim of this study was to investigate the effect of the aqueous extract (AE) of Achyrocline satureioides on serum lipid profile, liver oxidative profile and Na(+),K(+)-ATPase activity of rats submitted to a hyperlipidic diet. The animals were divided into four groups: control (C), AE 10% (A(10)), hyperlipidic (H) and hyperlipidic/AE 10% (HA(10)). In serum, we measured the levels of total cholesterol (TC), high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein (LDL) and triglyceride (TG). In liver homogenates, we measured the thiobarbituric acid reactive substances, the carbonyl proteins, the non-protein thiols (NPSHs) and the activity of superoxide dismutase, catalase (CAT) and Na(+),K(+)-ATPase. We observed a significant increase in the TC and LDL levels in the H group. A. satureioides prevented these effects, decreased the TG levels in the HA(10) group and increased the NPSH levels in the A(10) and HA(10) groups. The H group showed an increase in the carbonyl protein level and a decrease in CAT and Na(+),K(+)-ATPase activities. With the use of this model, results show that increased levels of lipids are related to a redox imbalance in the liver, which is also related to the inhibition of Na(+),K(+)-ATPase activity, and that chronic administration of the AE of A. satureioides is capable of changing this profile. |
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