Localisation of 7-12-Dimethylbenz(a)anthracene induced chromatid breaks and sister chromatid exchanges in chromosomes 1 and 2 of bone marrow cells of rat in vivo |
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| Authors: | A C van Kesteren-van Leeuwen A T Natarajan |
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| Institution: | (1) Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Wassenaarseweg 72, Leiden, The Netherlands;(2) J.A. Cohen Interuniversity Institute of Radiopathology and Radiation Protection, Rijnsburgerweg 86, Leiden, The Netherlands |
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| Abstract: | The frequency of chromatid breaks associated with sister chromatid exchanges at the break point was determined in rat bone marrow cells treated in vivo with 7–12 DMBA, during the late S phase of the cell cycle. The chromosomal aberrations and SCEs were scored in the same cells. Under the experimental conditions employed, more than 40% of the chromatid breaks were found to be associated with an SCE, a frequency expected according to Revell's hypothesis for the formation of chromatid breaks. |
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