首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Increased noise level of purkinje cell activities minimizes impact of their modulation during sensorimotor control
Authors:Hoebeek F E  Stahl J S  van Alphen A M  Schonewille M  Luo C  Rutteman M  van den Maagdenberg A M J M  Molenaar P C  Goossens H H L M  Frens M A  De Zeeuw C I
Institution:Department of Neuroscience, Erasmus MC, Dr. Molenwaterplein 50, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. f.hoebeek@erasmusmc.nl
Abstract:While firing rate is well established as a relevant parameter for encoding information exchanged between neurons, the significance of other parameters is more conjectural. Here, we show that regularity of neuronal spike activities affects sensorimotor processing in tottering mutants, which suffer from a mutation in P/Q-type voltage-gated calcium channels. While the modulation amplitude of the simple spike firing rate of their floccular Purkinje cells during optokinetic stimulation is indistinguishable from that of wild-types, the regularity of their firing is markedly disrupted. The gain and phase values of tottering's compensatory eye movements are indistinguishable from those of flocculectomized wild-types or from totterings with the flocculus treated with P/Q-type calcium channel blockers. Moreover, normal eye movements can be evoked in tottering when the flocculus is electrically stimulated with regular spike trains mimicking the firing pattern of normal simple spikes. This study demonstrates the importance of regularity of firing in Purkinje cells for neuronal information processing.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号