Synaptic localization of 5'-nucleotidase activity in the cerebellar cortex in adult rats irradiated by X rays after birth |
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| Authors: | Y Bailly S W Schoen N Delhaye-Bouchaud G W Kreutzberg J Mariani |
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| Institution: | Laboratoire de Neurobiologie du Développement, Institut des Neurosciences, C.N.R.S., Paris. |
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| Abstract: | 5'-nucleotidase cytochemistry was performed in the cerebellum of adult rats exposed previously to a single postnatal X-irradiation which maintains until adulthood the normally transient multiple innervation of cerebellar Purkinje cells by climbing fibers. 5'-nucleotidase activity persists in climbing fiber synapses and other asymmetrical synapses while it is transient during normal development. Therefore, in the X-irradiated rat, an immature stage of the excitatory synapses persists which, for the climbing fibers, co?ncides with or precedes their involution during normal development. |
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