Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria |
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| Authors: | He Haiyin Shen Bo Petersen Peter J Weiss William J Yang Hui Y Wang Ting-Zhong Dushin Russell G Koehn Frank E Carter Guy T |
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| Institution: | Department of Natural Products Chemistry, Chemical Sciences, Wyeth, Pearl River, NY 10965, USA. heh@wyeth.com |
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| Abstract: | A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin alpha (1) with potent activity against G+ bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity. |
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