TAK-778, a novel synthetic 3-benzothiepin derivative, promotes chondrogenesis in vitro and in vivo. |
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Authors: | H Akiyama A Fukumoto C Shigeno H Ito S Mukai T Hoshino H Makino T Nakamura |
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Institution: | Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University, Kyoto, Sakyo, 606-8507, Japan. akiy@kuhp.kyoto-u.ac.jp |
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Abstract: | TAK-778, a novel synthetic 3-benzothiepin derivative, stimulates the formation of cartilaginous nodules in mouse chondroprogenitor-like ATDC5 cells in vitro in association with upregulation of the gene expression of transforming growth factor-beta(2), but not bone morphogenetic protein-4 and insulin-like growth factor-I. One-shot injection of the TAK-778-containing sustained-release microcapsules accelerated the repair process of the full thickness defects of articular cartilage in rabbit knees. Our in vitro and in vivo results indicate that TAK-778 may be a therapeutically useful synthetic agent for articular cartilage repair. |
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