Drug-induced changes in lipid composition of E. coli and of mammalian cells in culture: ethanol, pentobarbital, and chlorpromazine. |
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Authors: | L O Ingram K D Ley E M Hoffmann |
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Institution: | 1. Department of Microbiology and Cell Science and Immunology and Medical Microbiology, University of Florida, Gainesville, Florida, 32611, USA;2. Sandia Laboratories, Organization 5441 Albuquerque, New Mexico 87115, USA |
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Abstract: | Both Chinese hamster ovary cells in culture and cells change their lipid composition when grown in the presence of ethanol, pentobarbital, and chlorpromazine. The effects of ethanol and the cross-tolerant drug, pentobarbital, are similar. Both cause a shift from 18:0 fatty acid to 16:0 fatty acids in CHO cells and a decrease in the proportion of saturated fatty acids in . Chlorpromazine, a non-cross-tolerant drug, causes the opposite effect in , a decrease in the proportion of unsaturated fatty acids. Chlorpromazine has little effect on the fatty acid composition of CHO cells. These changes in lipid composition are proposed as an adaptive response and a part of the mechanism for the development of drug tolerance. |
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