The lactate dehydrogenase of the icefish heart: biochemical adaptations to hypoxia tolerance |
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| Authors: | G Feller J P Pauly A Smal P O'Carra C Gerday |
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| Institution: | Laboratory of Biochemistry, University of Liege, Belgium. |
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| Abstract: | Cardiac lactate dehydrogenase from the hemoglobin- and myoglobin-free antarctic icefish has been purified by affinity chromatography. Structural and kinetic properties of the enzyme were found close or identical to those of its skeletal muscle counterpart and other M-type lactate dehydrogenases. A model involving a dual oxidative-anaerobic metabolism of the icefish heart is proposed. |
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