The influence of graft size on the induction of immunity versus tolerance to H-Y in H-2
k
strains of mice |
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Authors: | R B Ashman |
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Institution: | (1) Department of Microbiology, John Curtin School of Medical Research, Australian National University, ACT 2601 Canberra, Australia;(2) Clinical Immunology Research Unit, Princess Margaret Hospital, 6008 Subiaco, Western Australia;(3) Clinical Immunology Research Unit, Princess Margaret Hospital, 6008 Subiaco, Western Australia |
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Abstract: | Unprimed female CBA mice do not reject large (10 mm2) syngeneic male skin grafts. However, a high proportion do reject small (4 mm2) grafts. Nevertheless, rejection does not invariably result in an anamnestic response. In some cases, the immunity induced by the rejection of a small graft was overcome, and tolerance was induced by a subsequent challenge with a large graft. This suggests that the transplantation response to minor antigens is subject to active regulation, and screening of other H-2
k
strains indicates that the nature of the response (i. e., immunity or tolerance) is determined by a gene or genes mapping outside the major histocompatibility complex. |
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