| TRAM,LAG1 and CLN8: members of a novel family of lipid-sensing domains? |
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| 作者姓名： | Winter E Ponting CP |
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| 摘 要： |
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TRAM,LAG1 and CLN8: members of a novel family of lipid-sensing domains? |
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| Winter E,Ponting CP.TRAM,LAG1 and CLN8: members of a novel family of lipid-sensing domains?[J].Trends in Biochemical Sciences,2002,27(8):381-383. |
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| Authors: | Winter Eitan Ponting Chris P |
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| Institution: | MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK OX1 3QX. |
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| Abstract: | A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum. |
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