(1) Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical sciences, RaeBarali Road, 226014 Lucknow, India;(2) Industrial Toxicology Research Centre, Lucknow, India
Abstract:
Norepinephrine and dopamine have important role in movement disorders but their role in movement disorders associated with
Japanese encephalitis (JE) has not been evaluated. Therefore, in the present study, cerebrospinal fluid (CSF) catecholamine
levels and its metabolites in JE patients with movement disorders were compared with those without JE. CSF was collected by
lumbar puncture and analyzed by HPLC-ED. Norepinephrine, dopamine and homovanillic acid concentrations were significantly
(P<0.005) lower in JE patients compared to control groups. Low levels of catecholamines in JE associated movement disorders
compared to idiopathic Parkinson’s disease and other extrapyramidal symptoms may be due to severe structural damage to thalamus,
basal ganglia and brainstem in JE patients as revealed by MRI findings.