|
|||||
|
|
Silent chemoattractant receptors: D6 as a decoy and scavenger receptor for inflammatory CC chemokines |
|
| Authors: | Locati Massimo Torre Yeny Martinez de la Galliera Emanuela Bonecchi Raffaella Bodduluri Haribabu Vago Gianluca Vecchi Annunciata Mantovani Alberto |
| Affiliation: | aInstitute of General Pathology, Medical Faculty, University of Milan, I-20133 Milan, Italy bDepartment of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, I-20157 Milan, Italy cPathology Unit, L. Sacco Institute of Medical Science, University of Milan, I-20157 Milan, Italy dJames Graham Brown Cancer Center and The Department of Microbiology & Immunology, University of Louisville Health Sciences Center, KY-40202 Louisville, USA eICH, University of Milan, Milan, Italy |
| Abstract: | The chemokine system includes at least three “silent” receptors, DARC, D6 and CCX CKR, with distinct specificity and tissue distribution. D6 binds most inflammatory, but not homeostatic, CC chemokines and shuttles in a ligand-independent way from the plasma membrane to endocytic compartments where chemokines are targeted to degradation. In vitro and in vivo evidence, including results with gene-targeted mice, is consistent with the view that D6 acts as a decoy and scavenger for inflammatory CC chemokines. Thus, D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium to dampen inflammation in tissues and draining lymph nodes. |
| Keywords: | Chemokines Chemokine receptors Inflammation Decoy receptors D6 |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |