Adaptive response to chromosome damage in cultured human lymphocytes primed with low doses of X-rays |
| |
Authors: | Z Q Wang S Saigusa M S Sasaki |
| |
Institution: | Radiation Biology Center, Kyoto University, Japan. |
| |
Abstract: | Human lymphocytes exposed to 0.02 Gy of X-rays in the G1 but not the G0 phase became less susceptible to the induction of chromosome aberrations of the chromosome type by subsequent exposure to 3 Gy of X-rays. The induction of chromatid-type aberrations was not affected by the pretreatment with the priming dose. The expression of this adaptive-type response was transitory, being maximum at 5 h, and disappeared at 9 h after the initial low-dose exposure. Cell-cycle analysis excluded the possibility of a spurious consequence of differential cell-cycle progression. |
| |
Keywords: | |
|
|