The BglG group of antiterminators: a growing family of bacterial regulators |
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Authors: | Subramony Mahadevan |
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Affiliation: | (1) Developmental Biology and Genetics Laboratory, Indian Institute of Science, 560012 Bangalore, India |
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Abstract: | The product of the
bglG
gene of Escherichia
coli
was among the first bacterial antiterminators to be identified and characterized. Since the elucidation ten years ago of its
role in the regulation of the
bgl
operon
of E. coli,a large number of homologies have been discovered in both Gram-positive and Gram-negative bacteria. Often the homologues of
BglG in other organisms are also involved in regulating β-glucoside utilization. Surprisingly, in many cases, they mediate
antitermination to regulate a variety of other catabolic functions. Because of the high degree of conservation of the
cis-acting regulatory elements, antiterminators from one organism can function in another. Generally the antiterminator protein
itself is negatively regulated by phosphorylation by a component of the phosphotransferase system. This family of proteins
thus represents a highly evolved regulatory system that is conserved across evolutionarily distant genuses. |
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Keywords: | Bacterial antitermination RNA binding proteins response regulators phosphortransferase systems |
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