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S-Adenosylhomocysteine hydrolase activity during differentiation of HL-60 cells |
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| Authors: | Peter Chiba A. Plas J. M. C. Wessels C. H. M. M. De Bruyn |
| Affiliation: | (1) Department of Human Genetics, Faculty of Medicine, University of Nijmegen, The Netherlands;(2) Division of Hematology, Department of Medicine, University Hospital, St. Radboud, Nijmegen, The Netherlands |
| Abstract: | Early changes in S-adenosylhomocysteine (SAH) hydrolase activity during DMSO-induced granulocytic differentiation of HL-80 ceils were followed. Within 24 h a decrease of activity of SAH hydrolase could be detected in induced cultures but not in control cultures. This decrease could be shown to be associated with G1 phase of the cell cycle and was detected prior to phenotypic changes of the ceils. |
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